It sounds huge, with tons of headroom and a massive low end.
You can easily crank it up for smooth almost fuzz-like tones and the powerful 2-band EQ makes it easy to tailor the tones to match your amp and guitar.
Boosting with more mids boosted and compressed pedals, like the Tube Screamer and OCD, can often make a Muff sound muddy and almost choked.
Try placing the overdrive pedal in front of the Muff but be careful with the total amount of gain and volume. Some Big Muffs, like the Sovtek models and clones, are often best alone. All pedals listed below were tested on a Stratocaster featuring D Allen Voodoo 69 neck and middle pickups and a Seymour Duncan SSL5 bridge pickups and a Radix Deluxe PRS model with Seymour Duncan Phat Cat P90s into Reeves Custom 50 and Laney Lionheart L20h tube stacks.
Com score: 10/10 Electronic Orange Bananaboost The Bananaboost has that vintage flavour of the original.
In other words, knowing what amp you have, is crucial for understanding how overdrive and distortion pedals works and ultimately sound.
Read more about how to choose the right pedal for your amp here.
Big Muffs often sound better with a transparent booster placed after it, set for a very mild boost and EQ enhancement.
David often does this with either a Muff and Powerbooster or Tube Driver.